name: | Sorbitol |
ATC code: | A06AG07 | route: | oral |
n-compartments | 1 |
Sorbitol is a sugar alcohol used primarily as a laxative to treat constipation and to clear the bowel before diagnostic tests. It is also used as a sweetener in various pharmaceutical and food products. Sorbitol is approved and used in current medical practice, mainly for its osmotic laxative effects.
Estimated pharmacokinetic parameters for healthy adults after oral administration, as direct PK data on sorbitol in the published literature are not available.
Yang, D, et al., & Chen, J (2024). Bioequivalence Study of Epalrestat for Healthy Chinese Subjects. Clinical pharmacology in drug development 13(5) 485–490. DOI:10.1002/cpdd.1347 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37971280
Jain, NK, et al., & Pitchumoni, CS (1987). Sorbitol intolerance in adults. Prevalence and pathogenesis on two continents. Journal of clinical gastroenterology 9(3) 317–319. DOI:10.1097/00004836-198706000-00015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3611685
Matsui, K, et al., & Yokota, S (2021). Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 165 105934–None. DOI:10.1016/j.ejps.2021.105934 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34256099