.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AH02_Alvimopan.Alvimopan

Information

name:Alvimopan
ATC code:A06AH02
route:oral
n-compartments2

Alvimopan is a peripherally acting µ-opioid receptor antagonist used to accelerate the recovery of bowel function after bowel resection surgery. The drug reduces opioid-induced gastrointestinal side effects. It is approved for short-term inpatient use in adults undergoing bowel resection surgery.

Pharmacokinetics

Pharmacokinetic parameters are reported for healthy adult subjects after a single oral dose.

References

  1. Foss, JF, et al., & Schmith, VD (2008). Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials. Clinical pharmacology and therapeutics 83(5) 770–776. DOI:10.1038/sj.clpt.6100292 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17653140

Revisions

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