.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AH04_Naloxone.Naloxone_1

Information

name:Naloxone_1
ATC code:A06AH04_1
route:intramuscular
n-compartments2

Naloxone is an opioid antagonist used primarily to rapidly reverse opioid overdose. It binds to opioid receptors and can reverse and block the effects of other opioids, including respiratory depression, sedation, and hypotension. Naloxone is approved and widely used today both in emergency settings and by bystanders.

Pharmacokinetics

Pharmacokinetic parameters in healthy adults after intramuscular administration.

References

  1. Saari, TI, et al., & Dale, O (2024). Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. Clinical pharmacokinetics 63(4) 397–422. DOI:10.1007/s40262-024-01355-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38485851

  2. Dowling, J, et al., & Graudins, A (2008). Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers. Therapeutic drug monitoring 30(4) 490–496. DOI:10.1097/FTD.0b013e3181816214 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18641540

  3. Skulberg, AK, et al., & Dale, O (2018). Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers. European journal of clinical pharmacology 74(7) 873–883. DOI:10.1007/s00228-018-2443-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29568976

Revisions


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