.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AH05_Naldemedine.Naldemedine .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AH05_Naldemedine.Naldemedine| name: | Naldemedine | |
| ATC code: | A06AH05 | route: | oral |
| compartments: | 2 | |
| dosage: | 0.2 | mg |
| volume of distribution: | 155 | L |
| clearance: | 21.47 | L/h |
| other parameters in model implementation | ||
Naldemedine is a peripherally-acting μ-opioid receptor antagonist (PAMORA) used for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. It is an approved prescription medication, generally well-tolerated, and intended for oral administration.
Pharmacokinetic parameters in healthy adult subjects following a single oral dose of 0.2 mg.