name: | Glycerol |
ATC code: | A06AX01 | route: | oral |
n-compartments | 1 |
Glycerol (glycerin) is a simple polyol compound used medically as an osmotic laxative and for reducing intracranial or intraocular pressure. It is also used in a variety of pharmaceutical formulations and as a food additive. Glycerol is approved for medical use and is broadly regarded as safe.
Estimated pharmacokinetic parameters for adult healthy individuals derived from published secondary sources, as no study reports explicit compartmental model PK parameters for glycerol in humans.
de Jonge, ME, et al., & Beijnen, JH (2005). Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL. British journal of clinical pharmacology 59(3) 325–334. DOI:10.1111/j.1365-2125.2004.02325.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15752379
Liu, X, et al., & Leggas, M (2019). Pharmacokinetic modeling of the blood-stable camptothecin analog AR-67 in two different formulations. Biopharmaceutics & drug disposition 40(8) 265–275. DOI:10.1002/bdd.2199 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31292985
Gietka-Czernel, M, et al., & Zgliczyński, W (2020). Expert opinion on liquid L-thyroxine usage in hypothyroid patients and new liquid thyroxine formulation - Tirosint SOL [Opinia ekspertów dotycząca stosowania płynnej postaci lewotyroksyny oraz nowego preparatu Tirosint SOL u chorych na niedoczynność tarczycy]. Endokrynologia Polska 71(5) 441–465. DOI:10.5603/EP.a2020.0065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33202031