.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AX04_Linaclotide.Linaclotide .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A06A_DrugsForConstipation.A06AX04_Linaclotide.Linaclotide| name: | Linaclotide |
| ATC code: | A06AX04 | route: | oral |
| n-compartments | 1 |
Linaclotide is a guanylate cyclase-C agonist used for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults. It increases intestinal fluid secretion and transit. Linaclotide is currently approved and used for these indications.
Pharmacokinetics in healthy adults—parameters estimated based on available clinical summaries as linaclotide is minimally absorbed following oral administration and systemic exposures are negligible.