.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07B_IntestinalAdsorbents.A07BC02_Kaolin.Kaolin .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07B_IntestinalAdsorbents.A07BC02_Kaolin.Kaolin| name: | Kaolin | |
| ATC code: | A07BC02 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | L/h |
| other parameters in model implementation | ||
Kaolin is a naturally occurring clay mineral (hydrated aluminum silicate) historically used as an adsorbent in the treatment of diarrhea and as a gastrointestinal demulcent. It acts by binding toxins and bacteria in the gut. Its medical use for diarrhea has largely been discontinued in modern clinical practice and it is no longer a standard or approved treatment in most countries.
No human pharmacokinetic parameters have been reported in the scientific literature for kaolin as it is not systemically absorbed after oral administration; kaolin exerts its action locally in the gastrointestinal tract.
Jeunesse, EC, et al., & Toutain, PL (2013). Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog. BMC veterinary research 9 250–None. DOI:10.1186/1746-6148-9-250 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24330630