.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07B_IntestinalAdsorbents.A07BC03_Crospovidone.Crospovidone

Information

name:Crospovidone
ATC code:A07BC03
route:oral
n-compartments1

Crospovidone is a cross-linked form of polyvinylpyrrolidone (PVP) used as a tablet disintegrant in pharmaceutical formulations. It is an inert, insoluble polymer that rapidly absorbs water and swells, promoting tablet breakup and aiding in drug release. Crospovidone is not an active drug but a pharmaceutical excipient, and is not used for therapeutic treatment. It is generally recognized as safe and is approved for use in many countries.

Pharmacokinetics

No relevant pharmacokinetic publications are available for crospovidone in humans, as it is not absorbed or pharmacologically active. The compound is considered pharmacologically inert, non-bioavailable, and serves only as a disintegrant in solid oral dosage forms.

References

  1. Alsalhi, A, et al., & Batchelor, HK (2025). Flexible and dispersible paediatric oral formulations produced via extrusion spheronisation for the treatment of tuberculosis. International journal of pharmaceutics 678 125701–None. DOI:10.1016/j.ijpharm.2025.125701 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40350000

  2. Mittapalli, RK, et al., & Yamsani, MR (2010). Varying efficacy of superdisintegrants in orally disintegrating tablets among different manufacturers. Die Pharmazie 65(11) 805–810. PUBMED:https://pubmed.ncbi.nlm.nih.gov/21155386

Revisions


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