.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA05_LoperamideOxide.LoperamideOxide .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA05_LoperamideOxide.LoperamideOxide| name: | LoperamideOxide |
| ATC code: | A07DA05 | route: | oral |
| n-compartments | 1 |
Loperamide oxide is the N-oxide metabolite and prodrug of loperamide, which is a synthetic opioid used primarily as an anti-diarrheal agent. Loperamide oxide was developed to reduce central nervous system penetration compared to loperamide and is not approved for current clinical use.
No pharmacokinetic parameters for loperamide oxide in humans found in published literature. The following values are estimated based on its classification as a prodrug of loperamide and general properties of oral opioid receptor agonists used for local gut activity.