.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA06_Eluxadoline.Eluxadoline .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA06_Eluxadoline.Eluxadoline| name: | Eluxadoline |
| ATC code: | A07DA06 | route: | oral |
| n-compartments | 1 |
Eluxadoline is a mixed mu-opioid receptor agonist and delta-opioid receptor antagonist, utilized for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. It acts locally in the gastrointestinal tract, reducing bowel contractions and inhibiting pain signals. Eluxadoline is approved by regulatory agencies such as the FDA and EMA.
Pharmacokinetic data based on healthy adult subjects following oral administration of eluxadoline 100 mg.
Bonifacio, L, et al., & Covington, PS (2018). Evaluation of Eluxadoline Effect on Cardiac Repolarization. Clinical pharmacology in drug development 7(7) 727–736. DOI:10.1002/cpdd.453 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29659201