.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07E_IntestinalAntiinflammatoryAgents.A07EA02_Hydrocortisone.Hydrocortisone

Information

Hydrocortisone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, used primarily to treat conditions such as adrenal insufficiency, inflammation, allergic reactions, and certain autoimmune disorders. It is approved for clinical use today in various forms (oral, intravenous, topical, rectal) depending on the therapeutic indication.

Pharmacokinetics

Pharmacokinetic parameters derived from data in healthy adult volunteers after single oral dosing.

References

1. Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797

2. Werumeus Buning, J, et al., & van Beek, AP (2017). Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism: clinical and experimental 71 7–16. DOI:10.1016/j.metabol.2017.02.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28521880

3. Polito, A, et al., & Alvarez, JC (2016). Pharmacokinetics of oral fludrocortisone in septic shock. British journal of clinical pharmacology 82(6) 1509–1516. DOI:10.1111/bcp.13065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27416887

Revisions

• 06/2025 initial generated model