.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A08A_AntiobesityPreparationsExclDietProducts.A08AA04_Dexfenfluramine.Dexfenfluramine .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A08A_AntiobesityPreparationsExclDietProducts.A08AA04_Dexfenfluramine.Dexfenfluramine| name: | Dexfenfluramine | |
| ATC code: | A08AA04 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 30 | mg |
| volume of distribution: | 3.8 | L |
| clearance: | 45 | L/h |
| other parameters in model implementation | ||
Dexfenfluramine is a serotonergic anorectic agent, formerly used for the management of obesity. It is the dextroisomer of fenfluramine and acts primarily as a serotonin-releasing agent. Due to concerns over cardiac valvulopathy and pulmonary hypertension, dexfenfluramine was withdrawn from the market and is not approved for use today.
Pharmacokinetic parameters estimated for a typical healthy adult receiving oral dexfenfluramine, based on literature review and available pharmacology resources. No recent clinical PK studies available due to market withdrawal.