.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A10B_BloodGlucoseLoweringDrugsExclInsulins.A10BB02_Chlorpropamide.Chlorpropamide

Information

name:Chlorpropamide
ATC code:A10BB02
route:oral
n-compartments1

Chlorpropamide is a first-generation sulfonylurea oral hypoglycemic agent used to manage type 2 diabetes mellitus. It acts by stimulating pancreatic insulin secretion. The medication is largely replaced by newer agents due to a higher risk of hypoglycemia but may still be used in certain cases.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after a single oral dose.

References

  1. Roe, DA (1985). Drug-food and drug-nutrient interactions. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 5(6) 115–135. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3900336

  2. Xu, H, et al., & McLachlan, AJ (2009). Influence of genetic polymorphisms on the pharmacokinetics and pharmaco-dynamics of sulfonylurea drugs. Current drug metabolism 10(6) 643–658. DOI:10.2174/138920009789375388 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19799532

Revisions


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