.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A10B_BloodGlucoseLoweringDrugsExclInsulins.A10BD05_MetforminAndPioglitazone.MetforminAndPioglitazone .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A10B_BloodGlucoseLoweringDrugsExclInsulins.A10BD05_MetforminAndPioglitazone.MetforminAndPioglitazone| name: | MetforminAndPioglitazone |
| ATC code: | A10BD05 | route: | oral |
| n-compartments | 2 |
Metformin and pioglitazone is a fixed-dose combination medication used in the management of type 2 diabetes mellitus to improve glycemic control. Metformin is a biguanide that decreases hepatic glucose production and increases peripheral glucose uptake, while pioglitazone is a thiazolidinedione that increases insulin sensitivity. This combination is approved and widely used currently for lowering blood sugar levels in patients with type 2 diabetes who require more than one oral antidiabetic agent.
Estimated pharmacokinetic parameters for healthy adult subjects using known PK properties of metformin and pioglitazone administered together orally, as there is no published PK model for this specific fixed-dose combination product.