.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A11C_VitaminAAndDInclCombinationsOfTheTwo.A11CC04_Calcitriol.Calcitriol

Information

Calcitriol is the hormonally active form of vitamin D3 (1,25-dihydroxycholecalciferol), used in the management of hypocalcemia and bone disorders associated with chronic renal failure, hypoparathyroidism, and some other conditions. It is approved and commonly used clinically.

Pharmacokinetics

Pharmacokinetics of calcitriol in healthy adult volunteers following single intravenous dose administration.

References

1. Bailie, GR, & Johnson, CA (2002). Comparative review of the pharmacokinetics of vitamin D analogues. Seminars in dialysis 15(5) 352–357. DOI:10.1046/j.1525-139x.2002.00086.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12358640

2. Hu, K, et al., & Cui, Y (2021). Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers. Clinical pharmacology in drug development 10(1) 22–29. DOI:10.1002/cpdd.797 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32250057

3. Thirumaran, RK, et al., & Schuetz, EG (2012). Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochemical pharmacology 84(1) 104–112. DOI:10.1016/j.bcp.2012.03.017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22484315

Revisions

• 06/2025 initial generated model