.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A11D_VitaminB1PlainAndInCombinationWithVitaminB6AndB1.A11DA02_Sulbutiamine.Sulbutiamine .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A11D_VitaminB1PlainAndInCombinationWithVitaminB6AndB1.A11DA02_Sulbutiamine.Sulbutiamine| name: | Sulbutiamine | |
| ATC code: | A11DA02 | route: | oral |
| compartments: | 1 | |
| dosage: | 400 | mg |
| volume of distribution: | 30 | L |
| clearance: | 1.5 | L/h |
| other parameters in model implementation | ||
Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) developed for the treatment of asthenia, a condition characterized by chronic fatigue and lack of energy, and has also been researched as a cognitive enhancer and for its potential effects on memory function. Sulbutiamine is not approved for pharmaceutical use in the United States but is available as a supplement in some countries and used as a prescription medication in France and Japan.
Pharmacokinetic parameters estimated for healthy adult subjects after oral administration. There are no peer-reviewed publications providing full compartmental PK models with numerical parameters for sulbutiamine; the following values are estimates based on known properties of thiamine derivatives and published plasma time-concentration curves in non-peer-reviewed reports.