.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A11H_OtherPlainVitaminPreparations.A11HA07_Inositol.Inositol .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A11H_OtherPlainVitaminPreparations.A11HA07_Inositol.Inositol| name: | Inositol |
| ATC code: | A11HA07 | route: | oral |
| n-compartments | 1 |
Inositol is a carbocyclic sugar, classified as a vitamin-like compound, and is involved in cellular signaling as a component of phospholipids in cell membranes. It is used as a dietary supplement and has been investigated for use in various conditions including polycystic ovary syndrome (PCOS), psychiatric disorders, and as a supportive agent in metabolic syndrome. Inositol is not classified as an essential nutrient or a registered pharmaceutical, but is widely available as an over-the-counter supplement.
Estimated PK parameters for healthy adults after oral administration as direct clinical PK data are limited. No published peer-reviewed pharmacokinetic studies in humans providing comprehensive compartmental parameters could be identified.
Kaku, K (2014). Efficacy of voglibose in type 2 diabetes. Expert opinion on pharmacotherapy 15(8) 1181–1190. DOI:10.1517/14656566.2014.918956 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24798092
Kim, HS, et al., & Shin, JG (2018). Pharmacodynamic effects of voglibose administered alone, administered with metformin, and administered with metformin in a fixed-dose combination in healthy Korean subjects . International journal of clinical pharmacology and therapeutics 56(11) 544–550. DOI:10.5414/CP203146 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30178742
Ek, B, & Nahorski, S (1988). Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle. Biochemical pharmacology 37(23) 4461–4467. DOI:10.1016/0006-2952(88)90661-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2849446