.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A12A_Calcium.A12AA01_CalciumPhosphate.CalciumPhosphate .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A12A_Calcium.A12AA01_CalciumPhosphate.CalciumPhosphate| name: | CalciumPhosphate |
| ATC code: | A12AA01 | route: | oral |
| n-compartments | 1 |
Calcium phosphate is an inorganic mineral salt used as a calcium supplement in the treatment and prevention of calcium deficiency. It is utilized in various formulations (tribasic, dibasic, monobasic) for dietary supplementation, antacid, and as a pharmaceutical excipient. Not typically considered a drug with systemic pharmacological action, it is approved and widely used today as a supplement rather than a primary therapeutic agent.
No detailed pharmacokinetic model or parameter has been directly reported for calcium phosphate in humans, since its main function is to provide elemental calcium, which is absorbed via the gastrointestinal tract. The PK parameters below are estimated based on literature for oral calcium salts in healthy adults.
Hicks, J, et al., & Flaitz, C (2004). Biological factors in dental caries: role of remineralization and fluoride in the dynamic process of demineralization and remineralization (part 3). The Journal of clinical pediatric dentistry 28(3) 203–214. DOI:10.17796/jcpd.28.3.w0610427l746j34n PUBMED:https://pubmed.ncbi.nlm.nih.gov/15163148
Liu, Y, et al., & Hunziker, EB (2018). The kinetics and mechanism of bone morphogenetic protein 2 release from calcium phosphate-based implant-coatings. Journal of biomedical materials research. Part A 106(9) 2363–2371. DOI:10.1002/jbm.a.36398 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29569828