.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A12C_OtherMineralSupplements.A12CA01_SodiumChloride.SodiumChloride

Information

name:SodiumChloride
ATC code:A12CA01
route:intravenous
n-compartments1

Sodium chloride is an essential electrolyte that is widely used in medicine as an isotonic solution for fluid and electrolyte replenishment, intravenous hydration, and as a vehicle for the administration of parenteral drugs. It is approved and routinely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters are not routinely measured for sodium chloride as a therapeutic agent, because it is an endogenous substance with rapid distribution and elimination dependent on homeostatic renal mechanisms. The following estimates are provided for a typical healthy adult after intravenous administration.

References

  1. Parker, SL, et al., & Roberts, JA (2018). Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of critical care 47 15–20. DOI:10.1016/j.jcrc.2018.05.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29883885

  2. Liu, Y, et al., & Wang, X (2023). Pharmacokinetics and safety of injected ornidazole compared to its enantiomer levornidazole in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics 61(12) 543–550. DOI:10.5414/CP204442 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37840522

  3. Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703

Revisions


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