.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AA03_Glutamine.Glutamine .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AA03_Glutamine.Glutamine| name: | Glutamine |
| ATC code: | A16AA03 | route: | intravenous |
| n-compartments | 1 |
Glutamine is an amino acid widely used as a nutritional supplement for support during severe illness, trauma, or gastrointestinal disorders. It is not considered an 'approved drug' under a specific indication, but glutamine supplementation is often used in parenteral nutrition, particularly in critically ill or surgical patients to support immune function and gut integrity.
Estimated pharmacokinetic parameters for healthy adults; published data on pharmacokinetics for exogenous glutamine are extremely limited.
Manzanares, W, et al., & Heyland, DK (2015). Pharmaconutrition with selenium in critically ill patients: what do we know?. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 30(1) 34–43. DOI:10.1177/0884533614561794 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25524883
Ziegler, TR, et al., & Wilmore, DW (1990). Safety and metabolic effects of L-glutamine administration in humans. JPEN. Journal of parenteral and enteral nutrition 14(4 Suppl) 137S–146S. DOI:10.1177/0148607190014004201 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2119459
Wang, X, et al., & Vilchez, RA (2021). Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events. Clinical pharmacokinetics 60(12) 1557–1567. DOI:10.1007/s40262-021-01047-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34125423