.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AX04_Nitisinone.Nitisinone .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AX04_Nitisinone.Nitisinone| name: | Nitisinone |
| ATC code: | A16AX04 | route: | oral |
| n-compartments | 1 |
Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase used primarily in the treatment of hereditary tyrosinemia type 1 (HT-1). It is also studied for alkaptonuria. Nitisinone is an approved and widely used drug in many countries for HT-1 management.
Pharmacokinetic parameters in adult and pediatric patients with hereditary tyrosinemia type 1 receiving oral nitisinone therapy.
Sterkel, M, et al., & Oliveira, PL (2016). Tyrosine Detoxification Is an Essential Trait in the Life History of Blood-Feeding Arthropods. Current biology : CB 26(16) 2188–2193. DOI:10.1016/j.cub.2016.06.025 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27476595