.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AX08_Teduglutide.Teduglutide .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AX08_Teduglutide.Teduglutide| name: | Teduglutide |
| ATC code: | A16AX08 | route: | subcutaneous |
| n-compartments | 1 |
Teduglutide is a recombinant analog of human glucagon-like peptide-2 (GLP-2) used for the treatment of short bowel syndrome (SBS) in adult and pediatric patients who are dependent on parenteral nutrition. It enhances intestinal absorption by promoting mucosal growth, increasing intestinal blood flow, and reducing gastric motility. It is approved and in current use.
Pharmacokinetic parameters reported for healthy adult subjects following subcutaneous administration.
Marier, JF, et al., & Wallens, J (2010). Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients with short bowel syndrome and Crohn's disease. Journal of clinical pharmacology 50(1) 36–49. DOI:10.1177/0091270009342252 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19773525
Nave, R, et al., & Hartmann, M (2013). Pharmacokinetics of teduglutide in subjects with renal impairment. European journal of clinical pharmacology 69(5) 1149–1155. DOI:10.1007/s00228-012-1455-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23187965
Roepcke, S, et al., & Facius, A (2014). Utility of a population pharmacokinetic meta analysis during the approval process of teduglutide for the treatment of short bowel syndrome. International journal of clinical pharmacology and therapeutics 52(12) 1045–1058. DOI:10.5414/CP201942 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25066226