.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A16A_OtherAlimentaryTractAndMetabolismProducts.A16AX22_TiomolibdicAcid.TiomolibdicAcid

Information

name:TiomolibdicAcid
ATC code:A16AX22
route:oral
n-compartments1

Tiomolibdic acid, also known as bis-choline tetrathiomolybdate, is a chelating agent mainly investigated for the treatment of Wilson's disease, a rare genetic disorder of copper metabolism. It acts by binding copper and preventing its toxic accumulation. It is not approved in all countries for clinical use but has received orphan drug designation and has been approved in the EU under the name Cufence.

Pharmacokinetics

No published clinical pharmacokinetic studies reporting specific parameters for tiomolibdic acid (bis-choline tetrathiomolybdate) in humans were identified. The following parameters are estimated based on typical values for chelating agents administered orally.

References

  1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

  2. Keizer, RJ, et al., & Beijnen, JH (2010). Clinical pharmacokinetics of therapeutic monoclonal antibodies. Clinical pharmacokinetics 49(8) 493–507. DOI:10.2165/11531280-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20608753

  3. Echizen, H (2016). The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations. Clinical pharmacokinetics 55(4) 409–418. DOI:10.1007/s40262-015-0326-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26369775

Revisions


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