name: | Fluindione |
ATC code: | B01AA12 | route: | oral |
n-compartments | 1 |
Fluindione is a vitamin K antagonist anticoagulant (coumarin derivative) that was historically used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It has been largely withdrawn or replaced by other anticoagulants in most countries and is not widely used today.
Pharmacokinetic parameters estimated for a typical adult following oral administration (estimates; no referenced clinical PK source found).
Mentré, F, et al., & Lechat, P (1998). Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients. Clinical pharmacology and therapeutics 63(1) 64–78. DOI:10.1016/S0009-9236(98)90122-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9465843
Comets, E, et al., & Mentré, F (2012). Pharmacokinetic and pharmacodynamic variability of fluindione in octogenarians. Clinical pharmacology and therapeutics 91(5) 777–786. DOI:10.1038/clpt.2011.309 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22472992
Verstuyft, C, et al., & Becquemont, L (2012). A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy. Clinical pharmacokinetics 51(1) 41–53. DOI:10.2165/11595560-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22149257