.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B01A_AntithromboticAgents.B01AE05_Ximelagatran.Ximelagatran

Information

name:Ximelagatran
ATC code:B01AE05
route:oral
n-compartments1

Ximelagatran is an oral direct thrombin inhibitor anticoagulant, formerly used for prevention of stroke and venous thromboembolism, as well as for the treatment of deep vein thrombosis. It was withdrawn from the market due to hepatotoxicity concerns and thus is not approved or used today.

Pharmacokinetics

Pharmacokinetic parameters from healthy adult volunteers (both sexes) under fasting conditions after oral administration.

References

  1. Eriksson, UG, et al., & Eriksson, BI (2003). Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis. Clinical pharmacokinetics 42(7) 687–701. DOI:10.2165/00003088-200342070-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12844328

  2. Bååthe, S, et al., & Eriksson, UG (2006). Population pharmacokinetics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in atrial fibrillation patients receiving long-term anticoagulation therapy. Clinical pharmacokinetics 45(8) 803–819. DOI:10.2165/00003088-200645080-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16884319

  3. Wolzt, M, et al., & Eriksson, UG (2005). Pharmacokinetics and pharmacodynamics of ximelagatran. Seminars in vascular medicine 5(3) 245–253. DOI:10.1055/s-2005-916163 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16123911

Revisions


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