.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B01A_AntithromboticAgents.B01AF03_Edoxaban.Edoxaban

Information

Edoxaban is an oral, direct factor Xa inhibitor anticoagulant used for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. It is approved in several countries including the US, EU, and Japan.

Pharmacokinetics

Pharmacokinetic parameters after administration of 60 mg oral dose in healthy adult subjects (male and female).

References

1. Elenjickal, EJ, et al., & Mavrakanas, TA (2024). Anticoagulation in Patients with Chronic Kidney Disease. American journal of nephrology 55(2) 146–164. DOI:10.1159/000535546 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38035566

2. Martin, KA, et al., & Moll, S (2017). Oral Anticoagulant Use After Bariatric Surgery: A Literature Review and Clinical Guidance. The American journal of medicine 130(5) 517–524. DOI:10.1016/j.amjmed.2016.12.033 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28159600

3. Dunois, C (2021). Laboratory Monitoring of Direct Oral Anticoagulants (DOACs). Biomedicines 9(5) –. DOI:10.3390/biomedicines9050445 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33919121

Revisions

• 06/2025 initial generated model