.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CA01_Cetylpyridinium.Cetylpyridinium .Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CA01_Cetylpyridinium.Cetylpyridinium| name: | Cetylpyridinium |
| ATC code: | B05CA01 | route: | oral |
| n-compartments | 1 |
Cetylpyridinium is a quaternary ammonium compound with antiseptic properties, commonly used as a cationic surfactant and disinfectant. It is mainly used in oral care products such as mouthwashes and lozenges for its antibacterial activity against Gram-positive bacteria. Cetylpyridinium is not typically used systemically and lacks clinical approval for systemic therapeutic indications. It remains an approved agent in oral hygiene.
No published data available for human systemic pharmacokinetics. Systemic exposure is negligible due to local use and minimal absorption. Parameters are estimated based on physicochemical profile and assumptions.
Matsuo, K, et al., & Van Meerbeek, B (2019). Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite. Acta biomaterialia 100 388–397. DOI:10.1016/j.actbio.2019.09.045 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31568874
Kozak, KM, et al., & White, DJ (2005). Efficacy of a high bioavailable cetylpyridinium chloride mouthrinse over a 24-hour period: a plaque imaging study. American journal of dentistry 18 Spec No 18A–23A. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16178132