.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CA02_Chlorhexidine.Chlorhexidine .Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CA02_Chlorhexidine.Chlorhexidine| name: | Chlorhexidine |
| ATC code: | B05CA02 | route: | oral |
| n-compartments | 1 |
Chlorhexidine is a bisbiguanide antiseptic and disinfectant used primarily for skin disinfection before surgery and for sterilizing surgical instruments. It is also widely used as a topical antimicrobial agent in mouthwashes for gingivitis. Chlorhexidine is approved and routinely used today; however, systemic administration is rare due to low absorption and potential toxicity.
Pharmacokinetic estimates for healthy adult humans after accidental oral and intravenous exposure, as well as repeat oral and topical usage. Due to very poor oral absorption, limited systemic PK data exist. Typical PK parameters are modeled based on known ADME features and preclinical/infrequent clinical reports.
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