.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CB01_SodiumChloride.SodiumChloride

Information

Sodium chloride, commonly known as table salt, is an essential electrolyte involved in maintaining osmotic balance, nerve conduction, and muscle function. It is widely used in clinical practice as an intravenous infusion to treat or prevent sodium and chloride ion imbalances, dehydration, and as a vehicle for drug administration. Sodium chloride (saline) infusions are approved and routinely used worldwide.

Pharmacokinetics

Pharmacokinetic parameters estimated for healthy adult humans after intravenous administration of isotonic saline (0.9% sodium chloride) solution.

References

1. Parker, SL, et al., & Roberts, JA (2018). Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of critical care 47 15–20. DOI:10.1016/j.jcrc.2018.05.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29883885

2. Liu, Y, et al., & Wang, X (2023). Pharmacokinetics and safety of injected ornidazole compared to its enantiomer levornidazole in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics 61(12) 543–550. DOI:10.5414/CP204442 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37840522

3. Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703

Revisions

• 06/2025 initial generated model