name: | SodiumBicarbonate |
ATC code: | B05CB04 | route: | intravenous |
n-compartments | 1 |
Sodium bicarbonate is an alkalinizing agent used primarily to treat metabolic acidosis, severe renal impairment, certain drug intoxications, and to alkalinize urine. It is also used in emergency medicine for the management of hyperkalemia and some types of poisoning. Sodium bicarbonate is approved and widely used in clinical practice, typically administered intravenously in acute care settings.
Estimated pharmacokinetic parameters for adult patients; no specific publication reporting detailed pharmacokinetic modeling available. Mostly used intravenously in hospital and emergency settings.
Abumanhal-Masarweh, H, et al., & Schroeder, A (2019). Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society 296 1–13. DOI:10.1016/j.jconrel.2019.01.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30615983
Tarning, J, et al., & Jittamala, P (2024). Safety and pharmacokinetic properties of a new formulation of parenteral artesunate in healthy Thai volunteers. Malaria journal 23(1) 296–None. DOI:10.1186/s12936-024-05085-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39363296
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703