.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05C_IrrigatingSolutions.B05CX03_Glycine.Glycine

Information

name:Glycine
ATC code:B05CX03
route:intravenous
n-compartments1

Glycine is a simple amino acid that serves as an inhibitory neurotransmitter in the central nervous system. It is also used medically as a sterile, non-electrolyte irrigating solution during transurethral surgical procedures, particularly in urology. There is no current evidence supporting its use as an approved systemic drug for other therapeutic indications.

Pharmacokinetics

No direct pharmacokinetic studies for intravenous glycine irrigation solution in healthy adults or patients could be identified in published literature. Systemic glycine is rapidly and extensively distributed, metabolized primarily in the liver, and excreted renally. Values below are estimated based on related amino acid data and clinical context.

References

  1. Upert, G, et al., & Ermert, P (2021). Emerging peptide antibiotics with therapeutic potential. Medicine in drug discovery 9 100078–None. DOI:10.1016/j.medidd.2020.100078 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33398258

  2. Neumeister, A, et al., & Frost, JJ (2006). Cerebral metabolic effects of intravenous glycine in healthy human subjects. Journal of clinical psychopharmacology 26(6) 595–599. DOI:10.1097/01.jcp.0000245558.14284.aa PUBMED:https://pubmed.ncbi.nlm.nih.gov/17110816

  3. Bi, YA, et al., & Varma, MVS (2024). Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay. Clinical pharmacology and therapeutics 115(6) 1336–1345. DOI:10.1002/cpt.3215 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38404228

Revisions


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