.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05X_IVSolutionAdditives.B05XA02_SodiumBicarbonate.SodiumBicarbonate

Information

name:SodiumBicarbonate
ATC code:B05XA02
route:intravenous
n-compartments1

Sodium bicarbonate is an alkalinizing agent used to treat metabolic acidosis, severe renal disease, certain drug intoxications, and for alkalinization of urine. It is also used as an adjunct in cardiac arrest and some hyperkalemia cases. Sodium bicarbonate is an approved drug widely used in clinical settings.

Pharmacokinetics

Estimated pharmacokinetic parameters for adults, both sexes, with normal renal function. No specific published compartmental PK models in humans; values are estimated from clinical pharmacology sources.

References

  1. Abumanhal-Masarweh, H, et al., & Schroeder, A (2019). Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society 296 1–13. DOI:10.1016/j.jconrel.2019.01.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30615983

  2. Tarning, J, et al., & Jittamala, P (2024). Safety and pharmacokinetic properties of a new formulation of parenteral artesunate in healthy Thai volunteers. Malaria journal 23(1) 296–None. DOI:10.1186/s12936-024-05085-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39363296

  3. Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703

Revisions


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