name: | MagnesiumSulfate |
ATC code: | B05XA05 | route: | intravenous |
n-compartments | 2 |
Magnesium sulfate is an inorganic salt used in medicine for multiple applications, including the management of eclampsia and pre-eclampsia in obstetrics, as a tocolytic agent, for treating magnesium deficiency, and as an adjunct in severe asthma exacerbations. It is approved and widely used today, primarily by intravenous administration in clinical settings.
Pharmacokinetics reported in healthy adult volunteers, both male and female, after intravenous administration of magnesium sulfate.
da Costa, TX, et al., & Oliveira, AG (2020). Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors. Drugs in R&D 20(3) 257–266. DOI:10.1007/s40268-020-00315-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32642964
Brookfield, KF, et al., & Carvalho, B (2016). Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. American journal of obstetrics and gynecology 214(6) 737.e1–737.e7379. DOI:10.1016/j.ajog.2015.12.060 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26767791
Rower, JE, et al., & Finkelstein, Y (2025). Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. Journal of clinical pharmacology 65(6) 665–674. DOI:10.1002/jcph.6179 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39775569