.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B05X_IVSolutionAdditives.B05XA09_SodiumPhosphate.SodiumPhosphate

Information

Sodium phosphate is an inorganic phosphate salt used primarily as a laxative and bowel cleanser prior to colonoscopy and other medical procedures. It acts as an osmotic agent, drawing water into the intestines to induce bowel movement. Sodium phosphate is approved for use in many countries but oral formulations have some safety warnings due to risk of acute phosphate nephropathy.

Pharmacokinetics

Estimated pharmacokinetic parameters in healthy adults, as published human PK data for sodium phosphate is scarce. Estimates below are based on typical properties of inorganic phosphate pharmacokinetics.

References

1. Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865

2. Hoy, SM, et al., & Wagstaff, AJ (2009). Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser. Drugs 69(1) 123–136. DOI:10.2165/00003495-200969010-00009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19192941

3. Sampathkumar, K (2009). Niacin and analogs for phosphate control in dialysis--perspective from a developing country. International urology and nephrology 41(4) 913–918. DOI:10.1007/s11255-008-9497-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19037739

Revisions

• 06/2025 initial generated model