.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01A_CardiacGlycosides.C01AA05_Digoxin.Digoxin

Information

Digoxin is a cardiac glycoside derived from the foxglove plant Digitalis lanata. It is primarily used in the treatment of various heart conditions, notably atrial fibrillation, atrial flutter, and sometimes heart failure that cannot be controlled by other medications. Digoxin is approved and widely used in clinical practice today.

Pharmacokinetics

Typical pharmacokinetic parameters for adult healthy volunteers after oral administration.

References

1. Chen, R, et al., & Xia, ZL (2013). Population pharmacokinetics of digoxin in elderly patients. European journal of drug metabolism and pharmacokinetics 38(2) 115–121. DOI:10.1007/s13318-012-0107-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23096939

2. Bizjak, ED, & Mauro, VF (1997). Digoxin-macrolide drug interaction. The Annals of pharmacotherapy 31(9) 1077–1079. DOI:10.1177/106002809703100918 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9296249

3. Hirai, T, et al., & Shiga, T (2022). Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data. BMC pharmacology & toxicology 23(1) 14–None. DOI:10.1186/s40360-022-00552-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/35144695

Revisions

• 06/2025 initial generated model