.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01A_CardiacGlycosides.C01AA05_Digoxin.Digoxin_1

Information

name:Digoxin_1
ATC code:C01AA05_1
route:intravenous
compartments:2
dosage:0.5mg
volume of distribution:27.8L
clearance:9.88L/hr
other parameters in model implementation

Digoxin is a cardiac glycoside derived from the foxglove plant Digitalis lanata. It is primarily used in the treatment of various heart conditions, notably atrial fibrillation, atrial flutter, and sometimes heart failure that cannot be controlled by other medications. Digoxin is approved and widely used in clinical practice today.

Pharmacokinetics

Typical pharmacokinetic parameters for adult patients receiving intravenous bolus administration.

References

  1. Hornestam, B., Jerling, M., Karlsson, M.O. et al. Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the Digitalis in Acute Atrial Fibrillation trial. Eur J Clin Pharmacol 58, 747–755 (2003). DOI:10.1007/s00228-002-0553-3

  2. el-Desoky, ES, et al., & Derendorf, H (2005). Application of two-point assay of digoxin serum concentration in studying population pharmacokinetics in Egyptian pediatric patients with heart failure: does it make sense?. American journal of therapeutics 12(4) 320–327. DOI:10.1097/01.mjt.0000155108.62208.82 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16041195

  3. Huledal, G, et al., & van Hout, M (2007). Effect of NXY-059, a novel neuroprotectant, on the pharmacokinetics of a single dose of digoxin in healthy subjects. Current medical research and opinion 23(7) 1531–1539. DOI:10.1185/030079907x199646 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17559748

Revisions


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