modelDigoxin_IV_receptor_binding
Extends from Pharmacokinetic.Models.PK_1C.
Information
References:
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.0009 | Volume of distribution per kg (default 0.9 L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 1 | bioavailability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 2.7777777777777776e-7 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1e-4 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Info › Therapeutic range (metadata, not used in equations) | |||
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | maximal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Info › Substance metadata | |||
| Modelica.Units.SI.MolarMass | MM (from PK_1C) | 0 | molar mass [kg/mol]; 0 = not supplied (molar concentrations are then 0) |
| Info › Substance metadata (not used in equations) | |||
| Pharmacolibrary.Types.Dose | LD50 (from PK_1C) | 0 | median lethal dose [mg/kg]; 0 = unknown |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | central-compartment elimination half-life = ln(2)*Vd/Cl (1-compartment approximation; NOT the terminal half-life of 2-/3-compartment models) | |
| Pharmacokinetic.NoPerfusedTissueCompartment | intersticial | ||
| Pharmacokinetic.NoPerfusedTissueCompartment | receptor | ||
| Pharmacokinetic.NoPerfusedTissueCompartment | vascular |