.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01B_AntiarrhythmicsClassIAndIii.C01BA02_Procainamide.Procainamide

Information

Procainamide is a Class Ia antiarrhythmic drug used to treat and prevent various types of cardiac arrhythmias, including ventricular and supraventricular arrhythmias. It acts by blocking sodium channels in the heart. Procainamide is approved and still in clinical use, though less frequently than in the past due to alternative therapies and concerns regarding side effects.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers after intravenous administration.

References

1. Koup, JR, et al., & de Vries, TM (1998). Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets. Therapeutic drug monitoring 20(1) 73–77. DOI:10.1097/00007691-199802000-00014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9485559

2. Howard, PA (1999). Ibutilide: an antiarrhythmic agent for the treatment of atrial fibrillation or flutter. The Annals of pharmacotherapy 33(1) 38–47. DOI:10.1345/aph.18097 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9972384

3. Coyle, JD, et al., & Schaal, SF (1997). Evaluation of an open-loop, computer-based infusion system designed to achieve a series of constant, targeted plasma procainamide concentrations in patients undergoing electrophysiologic testing. Pharmacotherapy 17(3) 445–456. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9165549

Revisions

• 06/2025 initial generated model