.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01B_AntiarrhythmicsClassIAndIii.C01BA02_Procainamide.Procainamide_1

Information

name:Procainamide_1
ATC code:C01BA02_1
route:oral
n-compartments1

Procainamide is a Class Ia antiarrhythmic drug used to treat and prevent various types of cardiac arrhythmias, including ventricular and supraventricular arrhythmias. It acts by blocking sodium channels in the heart. Procainamide is approved and still in clinical use, though less frequently than in the past due to alternative therapies and concerns regarding side effects.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers after oral administration.

References

  1. Klotz, U (2007). Antiarrhythmics: elimination and dosage considerations in hepatic impairment. Clinical pharmacokinetics 46(12) 985–996. DOI:10.2165/00003088-200746120-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18027986

  2. Chow, MS, et al., & Hilleman, D (1988). Propafenone: a new antiarrhythmic agent. Clinical pharmacy 7(12) 869–877. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3061720

  3. Koup, JR, et al., & de Vries, TM (1998). Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets. Therapeutic drug monitoring 20(1) 73–77. DOI:10.1097/00007691-199802000-00014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9485559

Revisions


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