.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01B_AntiarrhythmicsClassIAndIii.C01BA03_Disopyramide.Disopyramide

Information

name:Disopyramide
ATC code:C01BA03
route:oral
n-compartments2

Disopyramide is a class IA antiarrhythmic agent used primarily to treat ventricular arrhythmias, atrial fibrillation, and other severe arrhythmias. It possesses potent sodium channel blocking properties, leads to slowed cardiac conduction, and has negative inotropic and anticholinergic effects. It is approved and in clinical use for cardiac arrhythmia management.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers after oral administration.

References

  1. Klotz, U (2007). Antiarrhythmics: elimination and dosage considerations in hepatic impairment. Clinical pharmacokinetics 46(12) 985–996. DOI:10.2165/00003088-200746120-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18027986

  2. Kelman, AW, et al., & Bryson, SM (1982). OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics. British journal of clinical pharmacology 14(2) 247–256. DOI:10.1111/j.1365-2125.1982.tb01969.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/7104175

Revisions


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