.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01B_AntiarrhythmicsClassIAndIii.C01BC03_Propafenone.Propafenone

Information

Propafenone is a class 1C antiarrhythmic drug used in the treatment and prevention of supraventricular and ventricular arrhythmias. It works primarily by blocking sodium channels in the heart, reducing excitability and conduction. Propafenone is FDA-approved and remains in clinical use today.

Pharmacokinetics

Typical adult healthy subjects, oral administration, single dose; non-poor metabolizers (extensive metabolizers)

References

1. Michaud, V, et al., & Turgeon, J (2006). Inhibitory effects of propafenone on the pharmacokinetics of caffeine in humans. Therapeutic drug monitoring 28(6) 779–783. DOI:10.1097/01.ftd.0000249945.64978.33 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17164694

2. Boriani, G, et al., & Magnani, B (1990). [Determination of oxidative phenotype in a sample population and correlation with the pharmacokinetics of propafenone]. Cardiologia (Rome, Italy) 35(2) 163–169. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2208201

3. Chow, MS, et al., & Hilleman, D (1988). Propafenone: a new antiarrhythmic agent. Clinical pharmacy 7(12) 869–877. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3061720

Revisions

• 06/2025 initial generated model