.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CA06_Phenylephrine.Phenylephrine

Information

Phenylephrine is a selective alpha-1 adrenergic receptor agonist used primarily as a decongestant, to increase blood pressure in hypotensive states such as shock, and as a mydriatic agent for ophthalmic procedures. It is approved for use via various routes including oral, intravenous, and topical administration. Injectable phenylephrine is used in hospital settings for acute hypotension.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration. Study included both males and females (mean age ~25-35 years).

References

1. Vincent, J, et al., & Reid, JL (1986). Racial differences in drug responses--a comparative study of trimazosin and alpha 1-adrenoceptor responses in normotensive Caucasians and West Africans. British journal of clinical pharmacology 21(4) 401–408. DOI:10.1111/j.1365-2125.1986.tb05214.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3011048

Revisions

• 06/2025 initial generated model