.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CA24_Epinephrine.Epinephrine

Information

Epinephrine (also known as adrenaline) is a catecholamine hormone and neurotransmitter used primarily for emergency treatment of severe allergic reactions (anaphylaxis), cardiac arrest, and sometimes severe asthma attacks. It is administered in various medical settings and is an approved drug still commonly used today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after intravenous administration.

References

1. Eugene, AR (2016). A Clinical Trial Simulation Evaluating Epinephrine Pharmacokinetics at various Dosing Frequencies during Cardiopulmonary Resuscitation. MEDtube science 4(2) 8–15. PUBMED:https://pubmed.ncbi.nlm.nih.gov/28435854

2. Yoo, H, et al., & Jusko, WJ (2015). Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects. European journal of clinical pharmacology 71(10) 1197–1207. DOI:10.1007/s00228-015-1913-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26233335

3. Hoegberg, LC, et al., & Gosselin, S (2016). Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clinical toxicology (Philadelphia, Pa.) 54(3) 167–193. DOI:10.3109/15563650.2015.1121270 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26853119

Revisions

• 06/2025 initial generated model