.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CE04_Bucladesine.Bucladesine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CE04_Bucladesine.Bucladesine| name: | Bucladesine |
| ATC code: | C01CE04 | route: | intravenous |
| n-compartments | 1 |
Bucladesine (dibutyryl cyclic AMP) is a synthetic analog of cyclic adenosine monophosphate (cAMP) that acts as a phosphodiesterase-resistant cAMP derivative. It was investigated for its use as a vasodilator and in the treatment of heart failure and peripheral vascular diseases. It is not currently approved or in clinical use.
No human pharmacokinetic parameter data are reported in the literature for bucladesine. The following represents an estimated one-compartment PK model for intravenous administration, reflecting typical parameters for small, hydrophilic nucleoside analogs. These figures are likely to be rough estimates and not derived from primary data.