.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CX08_Levosimendan.Levosimendan

Information

name:Levosimendan
ATC code:C01CX08
route:intravenous
n-compartments2

Levosimendan is a calcium sensitizer and potassium channel opener used for short-term treatment of acute decompensated severe chronic heart failure in adults. It enhances myocardial contractility without increasing myocardial oxygen demand. It is approved in various countries but not in the United States.

Pharmacokinetics

Population pharmacokinetics in adult patients with severe heart failure following intravenous administration.

References

  1. Jonsson, EN, et al., & Karlsson, MO (2003). Population pharmacokinetics of levosimendan in patients with congestive heart failure. British journal of clinical pharmacology 55(6) 544–551. DOI:10.1046/j.1365-2125.2003.01778.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12814448

  2. Antila, S, et al., & Lehtonen, LA (2007). Clinical pharmacology of levosimendan. Clinical pharmacokinetics 46(7) 535–552. DOI:10.2165/00003088-200746070-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17596101

  3. McBride, BF, & White, CM (2003). Levosimendan: implications for clinicians. Journal of clinical pharmacology 43(10) 1071–1081. DOI:10.1177/0091270003257217 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14517189

Revisions


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