.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CX09_AngiotensinIi.AngiotensinIi .Pharmacolibrary.Drugs.C_CardiovascularSystem.C01C_CardiacStimulantsExclCardiacGlycosides.C01CX09_AngiotensinIi.AngiotensinIi| name: | AngiotensinIi |
| ATC code: | C01CX09 | route: | intravenous |
| n-compartments | 1 |
Angiotensin II is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is used as a vasopressor for the treatment of hypotension, particularly in adults with septic or other distributive shock. It is approved for use in certain countries for this indication.
Pharmacokinetic parameters for angiotensin II are based on published data from clinical use in adult patients with distributive shock.
Csajka, C, et al., & Biollaz, J (2002). Population pharmacokinetic-pharmacodynamic modelling of angiotensin receptor blockade in healthy volunteers. Clinical pharmacokinetics 41(2) 137–152. DOI:10.2165/00003088-200241020-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11888333
Kim, TH, et al., & Shin, BS (2015). Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans. The AAPS journal 17(5) 1210–1223. DOI:10.1208/s12248-015-9764-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25990964