.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01D_VasodilatorsUsedInCardiacDiseases.C01DA08_IsosorbideDinitrate.IsosorbideDinitrate

Information

Isosorbide dinitrate is an organic nitrate used primarily as a vasodilator to prevent and treat angina pectoris due to coronary artery disease. It acts by relaxing smooth muscle and dilating blood vessels, thus decreasing cardiac workload and oxygen demand. The drug is approved and in clinical use for treatment of angina and sometimes heart failure.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects (mixed sex).

References

1. Leier, CV (1985). Nitrate tolerance. American heart journal 110(1 Pt 2) 224–232. DOI:10.1016/0002-8703(85)90491-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3925742

2. Liu, Z, et al., & Guo, R (2015). CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway. International journal of clinical pharmacology and therapeutics 53(4) 325–334. DOI:10.5414/CP202178 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25740261

Revisions

• 06/2025 initial generated model