.Pharmacolibrary.Drugs.C_CardiovascularSystem.C01E_OtherCardiacPreparations.C01EB22_Meldonium.Meldonium

Information

Meldonium (also known as mildronate) is a synthetic compound that inhibits carnitine biosynthesis. It was originally developed in Latvia and has been used as a metabolic modulator to treat ischemic heart disease, angina, and myocardial infarction, as well as for enhancing exercise tolerance. It is not FDA-approved in the United States, but has been used clinically in some post-Soviet states. Meldonium became widely known after being banned by WADA for use in athletes from 2016.

Pharmacokinetics

Healthy adult volunteers, both sexes, single oral dose.

References

1. Knych, HK, et al., & Kass, PH (2017). Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug testing and analysis 9(9) 1392–1399. DOI:10.1002/dta.2214 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28513092

Revisions

• 06/2025 initial generated model