.Pharmacolibrary.Drugs.C_CardiovascularSystem.C02A_AntiadrenergicAgentsCentrallyActing.C02AC01_Clonidine.Clonidine

Information

name:Clonidine
ATC code:C02AC01
route:oral
n-compartments2

Clonidine is a centrally acting alpha-2 adrenergic agonist commonly used for the treatment of hypertension and attention-deficit hyperactivity disorder (ADHD), and as adjunct therapy in opioid withdrawal and analgesia. It is approved and widely used in clinical practice.

Pharmacokinetics

PK parameters reported for healthy adult subjects after single oral administration.

References

  1. Larsson, P, et al., & Anderson, BJ (2011). Oral bioavailability of clonidine in children. Paediatric anaesthesia 21(3) 335–340. DOI:10.1111/j.1460-9592.2010.03397.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20735802

  2. De Hondt, L, et al., & Tommelein, E (2024). Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review. Frontiers in public health 12 1437328–None. DOI:10.3389/fpubh.2024.1437328 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39171321

  3. Bienert, A, et al., & Grześkowiak, E (2015). Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. Journal of clinical pharmacology 55(3) 307–316. DOI:10.1002/jcph.401 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25243731

Revisions


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