.Pharmacolibrary.Drugs.C_CardiovascularSystem.C02D_ArteriolarSmoothMuscleAgentsActingOn.C02DA01_Diazoxide.Diazoxide

Information

name:Diazoxide
ATC code:C02DA01
route:oral
n-compartments1

Diazoxide is a potassium channel activator used as a vasodilator in the treatment of acute hypertension and hypertensive emergencies. It is also used to manage hypoglycemia due to hyperinsulinism. Diazoxide is an approved drug but less commonly used today due to the availability of newer antihypertensive agents.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers, both sexes. Orally administered. Typical therapeutic dosing.

References

  1. Kizu, R, et al., & Hasegawa, T (2017). Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia. Hormone research in paediatrics 88(5) 316–323. DOI:10.1159/000478696 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28715810

  2. Ford, JL, et al., & Gonzalez, D (2022). Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity. Journal of clinical pharmacology 62(8) 960–969. DOI:10.1002/jcph.2034 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35119103

  3. Little, GL, & Boniface, KS (2005). Are one or two dangerous? Sulfonylurea exposure in toddlers. The Journal of emergency medicine 28(3) 305–310. DOI:10.1016/j.jemermed.2004.09.012 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15769574

Revisions


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